Site of action of different classes of antihypertensive drugs Antihypertensive drugs are directed against a variety of pharmacological targets in various cell types in different organs involved in blood pressure control. The most important targets in the brain, heart, vasculature (vascular smooth muscle cells), and the kidney (nephron) are shown. Some diuretics produce some direct [...]
Effects of anticoagulants on the coagulation cascade Coumarin (Warfarin) and the vitamin K cycle Abbreviations: glu, glutamate; gla, y-carboxyglutamate. (Modified from [2], with permission from Chest.) Relative effects of UFH, LMWH, and fondaparinux on AT-mediated inhibition of factor Xa and thrombin (lla). AT-mediated inhibition of factor Xa and thrombin (lla). Whereas UFH catalyzes inhibition of [...]
Desensitization, internalization and recycling of β-adrenergic receptors Activation of β-adrenergic receptors causes their phosphorylation by members of the GRKs. Cytosolic β-arrestins then bind to the phosphorylated receptors and prevent further interaction with G-proteins. β-Arrestin-bound receptors assemble in clathrin-coated pits, where the complex appears to interact with other proteins, including dynamin and src-kinase. This leads (i) [...]
