Synthesis and release of noradrenaline and adrenaline from sympathetic nerve endings (left) and from the adrenal gland (right). Noradrenaline and adrenaline are synthesized from the precursor amino acid tyrosine and are stored at high concentrations in synaptic vesicles. Upon activation of sympathetic nerves or adrenal chromaffin cells, noradrenaline and adrenaline are secreted and can activate [...]
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Cardiologist
A Kinase Anchoring Proteins. Model of an A kinase anchoring protein. The unifying characteristic of A kinase anchoring proteins is the presence of a structurally conserved binding domain for the dimer of regulatory (R) subunits of PKA (RBD, regulatory subunit binding domain). In the inactive state, PKA forms a tetramer consisting of a dimer of [...]
Description of Medical Condition Right ventricular enlargement/ dysfunction and failure caused by pulmonary hypertension (increased right ventricular afterload) secondary to diseases of the lung, thorax, and pulmonary vasculature. • Acute cor pulmonale: acute dilatation or overload of the right ventricle secondary to massive pulmonary embolism • Chronic cor pulmonale: hypertrophy and dilatation of the right [...]
