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Cardiologist

Osmotic Diuretics: Mannitol

Indication Mannitol is used to promote diuresis in the treatment of oliguria or anuria caused by acute renal failure. Mannitol is also used to reduce increased intrac-ranial pressure associated with cerebral edema. Mechanism of Action Mannitol is an osmotic diuretic that increases the osmotic pressure of the glomerular filtrate, inhibits the tubular reabsorption of water [...]

Carbonic Anhydrase Inhibitors: Acetazolamide

Indication Acetazolamide is used to reduce intraocular pressure in glaucoma and as a diuretic. Acetazolamide may also be used in the treatment of hydrocephalus, refractory seizures, epilepsy, and altitude sickness. It is also use to treat secondary metabolic alkalosis. Mechanism of Action As a diuretic, acetazolamide initiates competitive, reversible inhibition of carbonic anhydrase, which results [...]

Amiloride

Indication Amiloride reduces potassium loss caused by other diuretics used in the management of hypertension or edema associated with congestive heart failure, hepatic cirrhosis, and hyperaldosteronism. Amiloride is usually used with other diuretics. Mechanism of Action Amiloride inhibits sodium-potassium ion exchange in the distal convoluted tubule by inhibiting cellular sodium transport mechanisms and inhibits hydrogen [...]