High Blood Pressure / Hypertension

The centrally acting antihypertensive drugs are one of the oldest classes still in use for the treatment of hypertension. As a group, their common and unique mechanism of action is to stimulate receptors in the brain that reduce sympathetic nervous system activity, and lower blood pressure, heart rate, and systemic vascular resistance while preserving cardiac [...]

A1-Adrenergic blockers (prazosin/Minipress, terazosin/Hytrin, and doxazosin/Cardura) are approved antihypertensive drugs with a generally favorable profile of safety and tolerability. They have not gained widespread sustained use in hypertension because of their relatively limited monotherapeutic efficacy and their tendency to cause significant first-dose hypotension and sustained postural hypotension, both of which are magnified by salt depletion [...]