Diuretics have been and remain an important class of antihypertensive agents. They are a critical component of the hypertension therapeutic regimen, particularly for patients with systolic hypertension, the elderly, African Americans and diabetic patients. In large controlled clinical trials, diuretic therapy has consistently lowered morbidity and mortality for cardiovascular disease as well as stroke. For [...]
Indication Chlorothiazide is used in the treatment of mild to moderate hypertension. Additionally, chlorothiazide is used for the treatment of edema caused by congestive heart failure, pregnancy, branchopulmonary dysplasia,nephrotic syndrome, or after cardiac surgery. Mechanism of Action Chlorothiazide is a thiazide diuretic whose primary site of action is the distal convoluted tubule and whose secondary [...]
Indication Mannitol is used to promote diuresis in the treatment of oliguria or anuria caused by acute renal failure. Mannitol is also used to reduce increased intrac-ranial pressure associated with cerebral edema. Mechanism of Action Mannitol is an osmotic diuretic that increases the osmotic pressure of the glomerular filtrate, inhibits the tubular reabsorption of water [...]
