Indication Management of moderate to severe hypertension. Mechanism of Action Hydralazine is a direct-acting vasodilator that exerts its effect on arterioles with little effect on veins and decreases systemic resistance. The precise mechanism of action is unknown. Dosing Infants/children: Oral: initial, 0.75 to 1 mg/kg/day P.O./N.G. in two to four divided doses, not to exceed [...]
Indication Prostaglandin E is used for the temporary maintenance of patency of the ductus arteriosus in neonates with ductal-dependant congenital heart disease until the patient can undergo an interventional procedure. Congenital heart defects that create ductal-dependent circulations include pulmonary atresia, critical pulmonary stenosis, tricuspid atresia, tetralogy of Fallot and pulmonary atresia without major aortopulmonary collaterals, [...]
Indication Treatment of significant systemic hypertension. I.V. fenoldopam may have advantages over sodium nitroprusside because it causes both a diuresis and natriuresis, is not associated with cyanide toxicity, and is not sensitive to light. In addition, rebound hypertension has not occurred after discontinuation of fenoldopam administered via continuous infusion. Mechanism of Action Fenoldopam is a [...]
