High Blood Pressure / Hypertension

Posts Related to Anticoagulants

• Antihypertensive Drugs

  Site of action of different classes of antihypertensive drugs Antihypertensive drugs are directed against a variety of pharmacological targets in various cell types in different organs involved in blood pressure control. The most important targets in the brain, heart, vasculature (vascular smooth muscle cells), and the kidney (nephron) are shown. Some diuretics produce some direct ...

• Vitamin K Antagonists

  Overview For many years, experts in the pulmonary hypertension field have strongly recommended anticoagulant therapy to treat pulmonary arterial hypertension patients, particularly those without associated diseases for which contraindications may exist. This recommendation is based on the fact there is an increased risk of thrombosis and thromboembolism as a result of the sluggish pulmonary blood ...

• Warfarin Sodium: Uses, Preparations

  Uses and Administration Warfarin is a coumarin anticoagulant used in the treatment and prophylaxis of thromboembolic disorders. It acts by depressing the hepatic vitamin Independent synthesis of coagulation factors II (prothrombin), VII, LX, and X, and of the anticoagulant protein C and its cofactor protein S. For an explanation of the coagulation cascade, see Haemostasis ...

• β-Adrenergic System

  Desensitization, internalization and recycling of β-adrenergic receptors Activation of β-adrenergic receptors causes their phosphorylation by members of the GRKs. Cytosolic β-arrestins then bind to the phosphorylated receptors and prevent further interaction with G-proteins. β-Arrestin-bound receptors assemble in clathrin-coated pits, where the complex appears to interact with other proteins, including dynamin and src-kinase. This leads (i) ...

• α-Adrenergic System

  Synthesis and release of noradrenaline and adrenaline from sympathetic nerve endings (left) and from the adrenal gland (right). Noradrenaline and adrenaline are synthesized from the precursor amino acid tyrosine and are stored at high concentrations in synaptic vesicles. Upon activation of sympathetic nerves or adrenal chromaffin cells, noradrenaline and adrenaline are secreted and can activate ...