Tenecteplase

By Cardiologist on November 26th, 2010

Drug Nomenclature

Synonyms: TNK-tPA; Tenecteplasa
BAN: Tenecteplase
USAN: Tenecteplase
INN: Tenecteplase [rINN (en)]
INN: Tenecteplasa [rINN (es)]
INN: Ténectéplase [rINN (fr)]
INN: Tenecteplasum [rINN (la)]
INN: Тенектеплас [rINN (ru)]
Chemical name: [103-l-Asparagine-117-l-glutamine-296-l-alanine-297-l-alanine-298-l-alanine-299-l-alanine]plasminogen activator (human tissue-type)
CAS: 191588-94-0
ATC code: B01AD11

Description. Tenecteplase is a 527 amino acid glycoprotein produced by recombinant DNA technology. It is a modified form of human tissue plasminogen activator.

Adverse Effects, Treatment, and Precautions

As for Streptokinase

Interactions

As for Streptokinase

Pharmacokinetics

After intravenous injection in patients with acute myocardial infarction, tenecteplase has a biphasic clearance from plasma with an initial half-life of 20 to 24 minutes and a terminal phase half-life of 90 to 130 minutes. It is cleared mainly by hepatic metabolism.

Uses and Administration

Tenecteplase is a thrombolytic drug. It converts plasminogen to plasmin, a proteolytic enzyme that has fibrinolytic effects. The mechanisms of fibrinolysis are discussed further under Haemostasis and Fibrinolysis on site. Tenecteplase is a fibrin-specific thrombolytic.

Tenecteplase is used similarly to streptokinase in acute myocardial infarction. It is given intravenously as a single bolus dose over 5 to 10 seconds as soon as possible after the onset of symptoms. The dose is based on body-weight and ranges from 30 mg in patients less than 60 kg to a maximum of 50 mg in those 90 kg or above.

Proprietary Preparations

Australia: Metalyse;

Austria: Metalyse;

Belgium: Metalyse;

Brazil: Metalyse;

Canada: TNKase;

Chile: Metalyse;

Czech Republic: Metalyse;

Denmark: Metalyse;

Finland: Metalyse;

France: Metalyse;

Germany; Metalyse;

Greece: Metalyse;

Hong Kong; Metalyse;

Hungary: Metalyse;

Ireland: Metalyse;

Italy: Metalyse;

Malaysia: Metalyse;

Mexico: Metalyse;

The Netherlands: Metalyse;

Norway: Metalyse;

New Zealand: Metalyse;

Poland: Metalyse;

Portugal: Metalyse;

Russia: Metalyse;

South Africa: Metalyse;

Spain: Metalyse;

Sweden: Metalyse;

Switzerland: Metalyse;

Thailand: Metalyse;

United Kingdom (UK): Metalyse;

United States of America (US and USA): TNKase.


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